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Synthesis of novel azanorbornylpurine derivatives
- 1.0376064 - ÚOCHB 2013 RIV GB eng J - Journal Article
Hřebabecký, Hubert - Dejmek, Milan - Dračínský, Martin - Šála, Michal - Leyssen, P. - Neyts, J. - Kaniaková, Martina - Krůšek, Jan - Nencka, Radim
Synthesis of novel azanorbornylpurine derivatives.
Tetrahedron. Roč. 68, č. 4 (2012), s. 1286-1298. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA MŠMT 1M0508; GA ČR(CZ) GA202/09/0806; GA MŠMT(CZ) LC554
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50110509
Keywords : azanorbornane * purines * coxsackievirus
Subject RIV: CC - Organic Chemistry
Impact factor: 2.803, year: 2012
Novel racemic derivatives of 6-chloropurine, adenine, and 6-(cyclopropylamino)purine substituted with 2-azanorbornane, 7-azanorbornane, and 7-azabenzonorbornane were synthesized. All target compounds were tested for antiviral activity (CVB3, HCV) and 6-chloropurine derivatives were evaluated for potential activity as agonists of the neuronal and muscle nicotinic acetylcholine receptor.
Permanent Link: http://hdl.handle.net/11104/0208565
Number of the records: 1