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The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population
- 1.0375938 - ÚMG 2013 RIV US eng J - Journal Article
Svobodová, Eliška - Krulová, Magdalena - Zajícová, Alena - Pokorná, Kateřina - Procházková, Jana - Trošan, Peter - Holáň, Vladimír
The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-Cell 17 population.
Stem Cells and Development. Roč. 21, č. 6 (2012), s. 901-910. ISSN 1547-3287. E-ISSN 1557-8534
R&D Projects: GA AV ČR KAN200520804; GA MŠMT 1M0506; GA ČR GAP304/11/0653; GA ČR GD310/08/H077; GA ČR(CZ) GAP301/11/1568
Institutional research plan: CEZ:AV0Z50520514
Keywords : mesenchymal stem cells * immunomodulation * T-cell development
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.670, year: 2012
Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor-β and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORγt and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions.
Permanent Link: http://hdl.handle.net/11104/0216423
Number of the records: 1