Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells

0373440 - BC 2012 RIV GB eng J - Journal Article
Slámová, M. - Skallová, A. - Páleníková, J. - Kopecký, Jan
Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells.
Parasite immunology. Roč. 33, č. 12 (2011), 654-660. ISSN 0141-9838. E-ISSN 1365-3024
R&D Projects: GA AV ČR IAA600960811; GA MŠMT(CZ) LC06009
Institutional research plan: CEZ:AV0Z60220518
Keywords : Borrelia * dendritic cell * immune modulation * Ixodes ricinus
Subject RIV: EC - Immunology
Impact factor: 2.601, year: 2011

Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-alpha and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia-DCs interaction.
Permanent Link: http://hdl.handle.net/11104/0206540