Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

0372287 - ÚMG 2012 RIV GB eng J - Journal Article
Kejík, Z. - Bříza, T. - Králová, Jarmila - Poučková, P. - Kral, A. - Martásek, P. - Král, V.
Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery.
Bioorganic and Medicinal Chemistry Letters. Roč. 21, č. 18 (2011), s. 5514-5520. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA ČR GA203/09/1311
Grant - others:MPO(CZ) FR-TI3/521; AV ČR(CZ) KAN200100801
Program: FR; KA
Institutional research plan: CEZ:AV0Z50520514
Keywords : combined cancer therapy * photodynamic therapy * targeted drug delivery
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.554, year: 2011

We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery system for cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targeting proteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system.
Permanent Link: http://hdl.handle.net/11104/0205641