Number of the records: 1
Ileal Peyer's Patches Are Not Necessary for Systemic B Cell Development and Maintenance and Do Not Contribute Significantly to the Overall B Cell Pool in Swine
- 1.0370664 - MBÚ 2012 RIV US eng J - Journal Article
Šinkora, Marek - Štěpánová, Kateřina - Butler, J. - Francis, D. - Santiago-Mateo, K. - Potočková, Hana - Kárová, Kristýna - Šinkorová, Jana
Ileal Peyer's Patches Are Not Necessary for Systemic B Cell Development and Maintenance and Do Not Contribute Significantly to the Overall B Cell Pool in Swine.
Journal of Immunology. Roč. 187, č. 10 (2011), s. 5150-5161. ISSN 0022-1767. E-ISSN 1550-6606
R&D Projects: GA MŠMT ME09089; GA ČR GAP502/10/0038
Institutional research plan: CEZ:AV0Z50200510
Keywords : ANTIBODY REPERTOIRE DEVELOPMENT * LYMPHOID-TISSUES * NEONATAL PIGLETS
Subject RIV: EC - Immunology
Impact factor: 5.788, year: 2011
Based on studies of sheep, the ileal Peyer’s patches (IPP) have been regard as a type of primary lymphoid tissue similar to the bursa of Fabricius in chicken. Since bursectomy results in B cell deficiency, we wondered if resection of the IPP of piglets would have a similar effect. Comparison of IPP resected, surgical shams and untreated germ-free piglets, all of which were later colonized with a defined commensal flora demonstrates that resection of the IPP did not alter the level and phenotype of B and T cells in lymphoid tissues and the blood during 10 weeks after surgery
Permanent Link: http://hdl.handle.net/11104/0204392
Number of the records: 1