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Assessment of Mitochondrial DNA as an Indicator of Islet Quality: An Example in Goto Kakizaki Rats
- 1.0370179 - FGÚ 2012 RIV US eng J - Journal Article
Alán, Lukáš - Špaček, Tomáš - Zelenka, Jaroslav - Tauber, Jan - Berková, Z. - Zacharovová, K. - Saudek, F. - Ježek, Petr
Assessment of Mitochondrial DNA as an Indicator of Islet Quality: An Example in Goto Kakizaki Rats.
Transplantation Proceedings. Roč. 43, č. 9 (2011), s. 3281-3284. ISSN 0041-1345. E-ISSN 1873-2623.
[World Congress of the International Pancreas and Islet Transplant Association /13./. Praha, 01.06.2011-04.06.2011]
R&D Projects: GA MZd NS10219
Institutional research plan: CEZ:AV0Z50110509
Keywords : type 2 diabetes * mtDNA * beta-cells
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 1.005, year: 2011
Diabetic Goto Kakizaki (GK) rats represent an established model of type 2 diabetes that exhibit an onset of pancreatic islet (PI) pathology characterized by islet hypertrophy with decreased number of insulin-secreting beta-cells. Among the remaining beta-cells, oxidative phosphorylation (OXPHOS) and consequently glucose-stimulated insulin secretion (GSIS) are impaired, perhaps owing to a deficit in mitochondrial DNA (mtDNA). We measured content of mtDNA compared to Wistar rats in different tissues and we found drastic decrease in number of mtDNA
Permanent Link: http://hdl.handle.net/11104/0204053
Number of the records: 1