Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses

0370115 - ÚMG 2012 RIV GB eng J - Journal Article
Pata, S. - Otáhal, Pavel - Brdička, Tomáš - Laopajon, W. - Mahasongkram, K. - Kasinrer, W.
Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses.
BMC Research Notes. Roč. 4, - (2011), s. 293. ISSN 1756-0500
Institutional research plan: CEZ:AV0Z50520514
Keywords : CD99 * MHC II * CD81
Subject RIV: EB - Genetics ; Molecular Biology

We analyzed the association of CD99 with other cell surface molecules involved in T cell activation. We demonstrate the association of MHC class I, MHC class II and tetraspanin CD81 with CD99 molecules on the cell surface. Association of CD99 with its partners was observed for both isoforms. In addition, we determined that CD99 is a lipid raft-associated membrane protein and is recruited into the immunologic synapse during T cell activation. The implication of CD99 on T cell activation was investigated. Inhibition of anti-CD3 induced T cell proliferation by an anti-CD99 monoclonal antibody was observed.
Permanent Link: http://hdl.handle.net/11104/0204010