SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling

0370084 - ÚMG 2012 RIV US eng J - Journal Article
Dráber, Peter - Vonková, Ivana - Štěpánek, Ondřej - Hrdinka, Matouš - Kucová, Markéta - Skopcová, Tereza - Otáhal, Pavel - Angelisová, Pavla - Hořejší, Václav - Yeung, M. - Weiss, A. - Brdička, Tomáš
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Molecular and Cellular Biology. Roč. 31, č. 22 (2011), s. 4550-4562. ISSN 0270-7306. E-ISSN 1098-5549
R&D Projects: GA MŠMT 1M0506; GA ČR GEMEM/09/E011
Institutional research plan: CEZ:AV0Z50520514
Keywords : SCIMP * transmembrane adaptor protein * MHC II
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.527, year: 2011

The discovery of a new palmitoylated transmembrane adaptor protein, termed SCIMP, is described. SCIMP is expressed in B cells and other professional APCs and is localized in the immunological synapse due to its association with tetraspanin-enriched microdomains. In B cells, it is constitutively associated with Lyn kinase and becomes tyrosine phosphorylated after major histocompatibility complex type II (MHC-II) stimulation. When phosphorylated, SCIMP binds to the SLP65 adaptor protein and also to the inhibitory kinase Csk. While the association with SLP65 initiates the downstream signaling cascades, Csk binding functions as a negative regulatory loop. The results suggest that SCIMP is involved in signal transduction after MHC-II stimulation and therefore serves as a regulator of antigen presentation and other APC functions.
Permanent Link: http://hdl.handle.net/11104/0203989