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Crystal structure of a monomeric retroviral protease solved by protein folding game players
- 1.0369853 - ÚOCHB 2012 RIV US eng J - Journal Article
Khatíb, F. - Dímaio, F. - Cooper, S. - Kazmierczyk, M. - Gilski, M. - Krzywda, S. - Zábranská, Helena - Pichová, Iva - Thompson, J. - Popovic, Z. - Jaskolski, M. - Baker, D.
Crystal structure of a monomeric retroviral protease solved by protein folding game players.
Nature Structural & Molecular Biology. Roč. 18, č. 10 (2011), s. 1175-1177. ISSN 1545-9993. E-ISSN 1545-9985
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : M-MPV protease * monomer * model * Foldit
Subject RIV: CE - Biochemistry
Impact factor: 12.712, year: 2011
Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.
Permanent Link: http://hdl.handle.net/11104/0203824
Number of the records: 1