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4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics
- 1.0369807 - ÚOCHB 2012 RIV GB eng J - Journal Article
Liboska, Radek - Snášel, Jan - Barvík, I. - Buděšínský, Miloš - Pohl, Radek - Točík, Zdeněk - Páv, Ondřej - Rejman, Dominik - Novák, Pavel - Rosenberg, Ivan
4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics.
Organic & Biomolecular Chemistry. Roč. 9, č. 24 (2011), s. 8261-8267. ISSN 1477-0520. E-ISSN 1477-0539
R&D Projects: GA ČR GA202/09/0193; GA AV ČR KAN200520801; GA MŠMT(CZ) LC06061
Institutional research plan: CEZ:AV0Z40550506
Keywords : 4'-alkoxy oligothymidylates * modified oligonucleotides * oligonucleotide hybridisation * RNA mimics
Subject RIV: CC - Organic Chemistry
Impact factor: 3.696, year: 2011
4´-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4´-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4´-methoxy or 4´-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2´-O-methyl-oligothymidylate. The 4´-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties.
Permanent Link: http://hdl.handle.net/11104/0203789
Number of the records: 1