Polyglutamate copolymers as a tissue-engineering platform: polymer scaffold modification through aminolysis of poly(.gamma.-benzyl-L-glutamate-co-2,2,2-.gamma.-trichlorethyl-L-glutamate)

0369730 - ÚMCH 2012 RIV GB eng J - Journal Article
Svobodová, Jana - Rypáček, František
Polyglutamate copolymers as a tissue-engineering platform: polymer scaffold modification through aminolysis of poly(.gamma.-benzyl-L-glutamate-co-2,2,2-.gamma.-trichlorethyl-L-glutamate).
European Polymer Journal. Roč. 48, č. 1 (2012), s. 183-190. ISSN 0014-3057. E-ISSN 1873-1945
R&D Projects: GA AV ČR KJB400500904; GA ČR GAP108/11/1857; GA MŠMT 1M0538
Institutional research plan: CEZ:AV0Z40500505
Keywords : poly(.gamma.-benzyl-L-glutamate) * 2,2,2-.gamma.-trichlorethyl-L-glutamate * fibres
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 2.562, year: 2012

Homopolymers of γ-benzyl-L-glutamate (BLG) and its copolymers with more reactive 2,2,2-γ-trichlorethyl-L-glutamate (TCEG) were synthesized by ROP of respective N-carboxyanhydrides (NCA). The feasibility of functional modification of polyglutamate films and fibres through aminolysis of glutamate side chains with 2-aminoethanol or with a 2-aminoethanol/1,6-diaminohexane mixture was studied. The progress and extent of polymer side chain modification were analyzed by following methods: (a) the conversion of aminolysis of BLG units alone was determined from the amount of released benzyl alcohol extracted into hexane and followed by HPLC analysis, (b) the conversion of aminolysis of TCEG units was calculated from elemental analysis, (c) the depth and extend of films surface modification was evaluated ATR IR measurements and (d) the amount of free amino groups, created by aminolysis with 1,6-diaminohexane, was quantified by reaction with 2,4,6-trinitrobenzenesulfonic acid.
Permanent Link: http://hdl.handle.net/11104/0006754