Molecular detection of human bacterial pathogens

0369559 - BC 2012 RIV US eng M - Monography Chapter
Rudenko, Natalia - Golovchenko, Maryna - Oliver, J. H., Jr. - Grubhoffer, Libor
Borrelia.
Molecular detection of human bacterial pathogens. Boca Raton: CRC Press, Taylor & Francis Group, 2011 - (Liu, D.), s. 1155-1168. ISBN 978-1-4398-1238-9
R&D Projects: GA MŠMT(CZ) LC06009; GA ČR GA206/09/1782
Institutional research plan: CEZ:AV0Z60220518
Keywords : Borrelia * Ixodid ticks * Borrelia burgdorferi sensu lato coplex
Subject RIV: EE - Microbiology, Virology

The current knowledge about Borrelia burgdorferi sl complex is summarised; morphological classification and genome organization discussed and a modern classification of Borrelia into different strains and groups is presented. The pathogenic potential of Borrelia strains not classically associated with human Lyme disease is also under discussion. The major part of the chapter is devoted to the clinical symptoms of Lyme borreliosis and to different methods of LB diagnosis with the main accent to the description of molecular approaches, PCR-based techniques in particular. It is underlined that these techniques represent rapid, reliable, simple, sensitive, cost and time-saving methods that do not require large amounts of material. In the conclusion the authors discuss the current urgent need in anti LD vaccine, the research on which is being conducted for decades already. At the moment, another generation of the vaccines – a vaccine against an arthropod vector – is under investigation.
Permanent Link: http://hdl.handle.net/11104/0203592