Monte Carlo simulation of PET images for injection dose optimization

0369540 - ÚTIA 2012 RIV GB eng C - Conference Paper (international conference)
Boldyš, Jiří - Dvořák, Jiří - Bělohlávek, O. - Skopalová, M.
Monte Carlo simulation of PET images for injection dose optimization.
Computational Vision and Medical Image Processing: VipIMAGE 2011. London: Taylor and Francis, 2011 - (Manuel, J.; Tavares, R.; Jorge, N.), s. 1-6. ISBN 978-0-415-68395-1.
[VipIMAGE 2011 - third ECCOMAS thematic conference on computational vision and medical image processing. Olhao, Algarve (PT), 12.10.2011-14.10.2011]
R&D Projects: GA MŠMT(CZ) 1M0572
Institutional research plan: CEZ:AV0Z10750506
Keywords : positron emission tomography * Monte Carlo simulation * biological system modeling * image quality
Subject RIV: BD - Theory of Information
http://library.utia.cas.cz/separaty/2012/ZOI/boldys-monte carlo simulation of pet images for injection dose optimization.pdf

When a patient is examined by positron emission tomography, radiotracer dose amount has to be determined. However, the rules used nowadays do not correspond with practical experience. Slim patients are given unnecessary amount of radiotracer and obese patients would need more activity to produce images of sufficient quality. We have built a model of a particular PET scanner and approximated human trunk, which is our region of interest, by a cylindrical model with segments of liver, outer adipose tissue and the rest. We have performed Monte Carlo simulations of PET imaging using the GATE simulation package. Under reasonably simplifying assumptions and for special parameters, we have developed curves, which recommend amount of injected activity based on body parameters to give PET images of constant quality. The dependence qualitatively differs from the rules used in clinical practice nowadays and the results indicate potential for improvement
Permanent Link: http://hdl.handle.net/11104/0203576