Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

0369494 - BTÚ 2012 RIV US eng J - Journal Article
Ralph, S.J. - Moreno-Sanchez, R. - Neužil, Jiří - Rodriguez-Enriquez, S.
Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death.
Pharmaceutical Research. Roč. 28, č. 11 (2011), s. 2695-2730. ISSN 0724-8741. E-ISSN 1573-904X
Institutional research plan: CEZ:AV0Z50520701
Keywords : Mitocans * SDH/Complex II * mitochondrial ROS production
Subject RIV: CE - Biochemistry
Impact factor: 4.093, year: 2011

Succinate:quinone reductase (SQR) of Complex II, occupying a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production, is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or increase ROS in cancer cells, inducing cell death. Value of drugs like diazoxide to prevent ROS production, protecting normal cells, while vitamin E analogues promote ROS in cancer cells to kill them, is highlighted. We collate and discuss diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to mitochondrial-targeted anticancer drugs (mitocans) as novel cancer therapies.
Permanent Link: http://hdl.handle.net/11104/0006745