Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain

0369481 - BTÚ 2012 RIV US eng J - Journal Article
Rohlena, Jakub - Dong, L.-F. - Ralph, S.J. - Neužil, Jiří
Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain.
Antioxidants & Redox Signaling. Roč. 15, č. 12 (2011), s. 2951-2974. ISSN 1523-0864. E-ISSN 1557-7716
R&D Projects: GA AV ČR(CZ) KAN200520703
Institutional research plan: CEZ:AV0Z50520701
Keywords : Targets for anticancer drugs * mitochondrial electron transport chain * mitocans
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.456, year: 2011

A group of compounds that induce mitochondrial destabilization affecting the physiology of cancer cells has been defined and termed 'mitocans.' We have placed these agents into several groups including hexokinase inhibitors, compounds targeting Bcl-2 proteins, thiol redox inhibitors, VDAC/ANT targeting drugs, electron transport chain-targeting drugs, lipophilic cations targeting the inner membrane, agents affecting the TCA cycle and drugs targeting mtDNA. Mitocans have a potential to prove efficient in suppressing various malignant diseases in a selective manner. They include compounds that offer promise to become clinically applied drugs. We redefine the individual classes of mitocans, providing examples of the various members of groups with a focus on agents targeting the electron transport chain. Even though ROS induction is important for the anticancer activity of many mitocans, the precise sequence of events is not yet fully clarified, and warrants further investigation.
Permanent Link: http://hdl.handle.net/11104/0203533