The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply

0369317 - BTÚ 2012 RIV US eng J - Journal Article
Horáček, J. - Tejkalová, H. - Novák, T. - Bubeníková-Valešová, V. - Páleníček, T. - Rambousek, L. - Růžičková, Šárka - Vaculín, Š. - Hoeschl, C.
The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply.
Psychological Medicine. Roč. 41, č. 8 (2011), s. 1787-1789. ISSN 0033-2917. E-ISSN 1469-8978
Institutional research plan: CEZ:AV0Z50520701
Keywords : serotonin * proinflammatory * cytokines
Subject RIV: AN - Psychology
Impact factor: 6.159, year: 2011

Psychiatric diseases are associated with elevated levels of pro-inflammatory cytokines in affected patients. Cytokines IL-1 and TNF- enhance the production of serotonin transporter (5-HT) thus, antidepressants could mediate their effect by downregulation of these cytokines. Therefore, we studied the influence of ketamine in male Wistar/Hann rats on IL-1 and TNF- and 5-HT activity in the blood and brain. Both cytokines increased up to 140% and 150% only in control animals, not in the ketamine group. Ketamine administration led to lower 5-HT levels in the hippocampus compared to controls (t=2.218, p<0.05). The hippocampal 5-HT levels correlated negatively with the basal TNF- and positively with the absolute and relative change of this cytokine in the whole sample, which suggests inhibition of IL-1 and TNF-activity. The mechanisms responsible for the interaction between the pro-inflammatory pathway, 5-HT and antidepressant effect of ketamine remain unknown
Permanent Link: http://hdl.handle.net/11104/0203412