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Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates

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    0369214 - ÚOCHB 2012 RIV CZ eng J - Journal Article
    Jansa, Petr - Kolman, Viktor - Kostinová, Alexandra - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
    Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates.
    Collection of Czechoslovak Chemical Communications. Roč. 76, č. 10 (2011), s. 1187-1198. ISSN 0010-0765
    R&D Projects: GA MV VG20102015046
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : nucleosides * nucleotides * phosphorus * fluorine * biological activity * antibiotics
    Subject RIV: CC - Organic Chemistry
    Impact factor: 1.283, year: 2011

    Efficient synthesis of acyclic nucleosides and acyclic nucleoside phosphonates substituted at the C-2′ position of the aliphatic part by the trifluoromethyl group is described, starting from trifluoromethyloxirane. None of the prepared compounds exhibit any antiviral, antiproliferative or anti-toxin activities.
    Permanent Link: http://hdl.handle.net/11104/0203334

     
     
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