Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord

0368699 - ÚEM 2012 RIV GB eng J - Journal Article
Perrin, F. E. - Gerber, Y. N. - Teigell, M. - Lonjon, N. - Boniface, G. - Bauchet, L. - Rodríguez Arellano, Jose Julio - Hugnot, J. P. - Privat, A. M.
Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord.
Cell Death & Disease. Roč. 2, - (2011), e218. ISSN 2041-4889. E-ISSN 2041-4889
R&D Projects: GA ČR GA309/09/1696; GA ČR(CZ) GAP304/11/0184
Institutional research plan: CEZ:AV0Z50390703
Keywords : genito-urinary tract * locomotion * nociceptive pathway
Subject RIV: FH - Neurology
Impact factor: 5.333, year: 2011

Here, we have performed a preliminary mapping of serotonergic processes and serotonin-lA (5-HT(1A)) receptors in thoracic and lumbar segments of the human spinal cord. 5-HT profiles in human spinal cord are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at lumbar level. 5-HT(1A) receptors are present in the same area, but are more densely expressed at lumbar level. These findings pave the way for local specific therapies involving cellular and/or pharmacological tools targeting the serotonergic system.
Permanent Link: http://hdl.handle.net/11104/0202973