N9-substituted derivatives of kinetin: Effective anti-senescence agents

0368599 - ÚEB 2012 RIV GB eng J - Journal Article
Mik, V. - Szüčová, Lucie - Šmehilová, M. - Zatloukal, Marek - Doležal, Karel - Nisler, Jaroslav - Grúz, Jiří - Galuszka, Petr - Strnad, Miroslav - Spíchal, Lukáš
N9-substituted derivatives of kinetin: Effective anti-senescence agents.
Phytochemistry. Roč. 72, č. 8 (2011), s. 821-831. ISSN 0031-9422. E-ISSN 1873-3700
R&D Projects: GA ČR GA522/09/1576; GA MŠMT ED0007/01/01; GA MŠMT(CZ) LC06034; GA ČR GA301/08/1649
Institutional research plan: CEZ:AV0Z50380511
Keywords : Cytokinin derivatives * Synthesis * Cytokinin activity * Senescence * Membrane damage
Subject RIV: EF - Botanics
Impact factor: 3.351, year: 2011

The first isolated cytokinin, 6-furfurylaminopurine (kinetin or Kin), was identified almost 55 years ago. Its biological effects on plant cells and tissues include influences on such processes as gene expression, cell cycle, chloroplast development, chlorophyll biosynthesis, stimulation of vascular development, delay of senescence, and mobilization of nutrients. In the present study we prepared a series of eight N9-substituted Kin derivatives, and characterized them with available physicochemical methods such as Cl+ mass spectrometry and (1)H NMR spectroscopy. All compounds were tested in three classical cytokinin bioassays: a tobacco callus assay, an Amaranthus assay, and a senescence assay with excised wheat leaves. The ability of the compounds to interact with Arabidopsis cytokinin receptors CRE1/AHK4 and AHK3 was tested in a bacterial receptor assay.
Permanent Link: http://hdl.handle.net/11104/0202898