Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair

0368381 - ÚEM 2012 RIV US eng J - Journal Article
Kubinová, Šárka - Horák, Daniel - Hejčl, Aleš - Plichta, Zdeněk - Kotek, Jiří - Syková, Eva
Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair.
Journal of Biomedical Materials Research. Part A. Roč. 99, č. 4 (2011), s. 618-629. ISSN 1549-3296. E-ISSN 1552-4965
R&D Projects: GA AV ČR IAA500390902; GA ČR GAP304/11/0731; GA ČR(CZ) GPP304/11/P633
Grant - others:GA AV ČR(CZ) KAN200520804; GA ČR(CZ) GAP108/10/1560; GA ČR(CZ) GAP304/11/0653; GA MŠk(CZ) 1M0538
Program: KA; GA; GA; 1M
Institutional research plan: CEZ:AV0Z50390703; CEZ:AV0Z40500505
Keywords : 2-hydroxyethyl methacrylate * scaffold * spinal cord repair
Subject RIV: FH - Neurology
Impact factor: 2.625, year: 2011

Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion.
Permanent Link: http://hdl.handle.net/11104/0202742