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Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis
- 1.0368248 - ÚEM 2012 RIV GB eng J - Journal Article
Forostyak, Serhiy - Jendelová, Pavla - Kapcalová, Miroslava - Arboleda Toro, David - Syková, Eva
Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis.
Cytotherapy. Roč. 13, č. 9 (2011), s. 1036-1046. ISSN 1465-3249. E-ISSN 1477-2566
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GAP304/11/0189
Grant - others:GA MŠk(CZ) 1M0538; GA ČR(CZ) GD309/08/H079
Program: 1M
Institutional research plan: CEZ:AV0Z50390703
Keywords : motor neurons * neurodegenerative diseases * stem cells
Subject RIV: FH - Neurology
Impact factor: 3.627, year: 2011
In current study transgenic rats overexpressing mutant human SOD1 were used as a model of fALS. We have found that grafting of MSC into symptomatic rats had a significant effect on motor activity and grip strength and longer lifespan if compared with the control group of animals. Transplanted cells survived and migrated in the spinal cord until the end stage of the disease without any side effects. Combined delivery of BM-derived MSC, therefore, could be an attractive approach for bench-to bedside studies in the treatment of ALS.
Permanent Link: http://hdl.handle.net/11104/0202644
Number of the records: 1