Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression

0368230 - ÚŽFG 2012 RIV CZ eng J - Journal Article
Dostál, Jaromír - Hrdlicová, Anna - Horák, Pavel
Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression.
Veterinární medicína. Roč. 56, č. 5 (2011), s. 243-247. ISSN 0375-8427. E-ISSN 1805-9392
Institutional research plan: CEZ:AV0Z50450515
Keywords : canine * retinitis pigmentosa * autosomal
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.748, year: 2011

Progressive rod-cone degeneration (PRCD) is a late onset autosomal photoreceptor degeneration found in canines. PRCD in canines is homologous to one form of retinitis pigmentosa (RP) found in humans and displays phenotypic similarity as well as having the identical causative mutation. The PRCD gene was mapped to the centromeric region of canine chromosome 9 (CFA9). We report here a population study of 699 dogs of the following breeds and the following frequencies of the disease-causing mutation: American Cocker Spaniel (0.09), English Cocker Spaniel (0.34), English Springer Spaniel (0.00), Welsh Springer Spaniel (0.00), Flat Coated Retriever (0.00), Golden Retriever (0.00), Chesapeake Bay Retriever (0.14), Nova Scotia Duck Tolling Retriever (0.44), Labrador Retriever (0.07), Poodle Toy (0.45), Poodle Miniature (0.20), Poodle Medium (0.05), Poodle Standard (0.00), Portuguese Water Dog (0.33), Chinese Crested Dog (0.02), Shipperke (0.06), and Australian Cattle Dog (0.00).
Permanent Link: http://hdl.handle.net/11104/0202628