Excitation Specificity of Repolarization Parameters

0368135 - ÚPT 2012 RIV US eng C - Conference Paper (international conference)
Halámek, Josef - Jurák, Pavel - Vondra, Vlastimil - Viščor, Ivo - Plachý, M. - Leinveber, P.
Excitation Specificity of Repolarization Parameters.
33rd Annual International IEEE EMBS Conference. Piscataway: IEEE, 2011, s. 961-964. ISBN 978-1-4244-4122-8. ISSN 1557-170X.
[Annual International IEEE EMBS Conference /33./. Boston (US), 30.08.2011-03.09.2011]
R&D Projects: GA MŠMT ME09050
Institutional research plan: CEZ:AV0Z20650511
Keywords : cardiovascular signal processing * ventricular models * ventricular arrhythmia mechanisms
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

The excitation specificity of QT dynamic parameters was tested on three groups of subjects: healthy subjects; non-medicated hypertensive subjects with metabolic syndrome; and subjects with essential hypertension. Four different excitations of RR were used: bicycling exercise; tilt with breathing 0.1 and 0.33 Hz; and deep breathing. Linear dynamic feedback model of QT/RR coupling was supposed at the analysis and next repolarization parameters were tested: QTc; gain of QT/RR coupling for slow and fast RR variability; time constant of QT adaptation; and random QT variability. Results: Dynamic repolarization parameters statistically significantly depend on the type of RR excitation. The gain of QT/RR coupling for slow RR variability, the time constant of QT adaptation and QTc are maximal at RR excitation given by the bicycling exercise. The frequency of breathing, i.e. corresponding vagal modulation has no effect on repolarization parameters.
Permanent Link: http://hdl.handle.net/11104/0202567