Nucleobase modification as redox DNA labelling for electrochemical detection

0368112 - ÚOCHB 2012 RIV GB eng J - Journal Article
Hocek, Michal - Fojta, Miroslav
Nucleobase modification as redox DNA labelling for electrochemical detection.
Chemical Society Reviews. Roč. 40, č. 12 (2011), s. 5802-5814. ISSN 0306-0012. E-ISSN 1460-4744
R&D Projects: GA MŠMT(CZ) LC06035; GA MŠMT LC512; GA AV ČR(CZ) IAA400040901; GA ČR GA203/09/0317
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : nucleotides * oligonucleotides * DNA * electrochemistry * redox labeling
Subject RIV: CC - Organic Chemistry
Impact factor: 28.760, year: 2011

Basic aspects of DNA electrochemistry with a strong focus on the use of modified nucleobases as redox probes for electrochemical bioanalysis are reviewed. Intrinsic electrochemical properties of nucleobases in combination with artificial redox-active nucleobase modifications are frequently applied in this field. Synthetic approaches to base-modified nucleic acids are briefly summarized and their applications in redox labelling are discussed.
Permanent Link: http://hdl.handle.net/11104/0202554