MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic

0367822 - ÚEM 2012 RIV NL eng J - Journal Article
Pardini, Barbara - Kumar, R. - Naccarati, Alessio - Prasad, R. B. - Försti, A. - Poláková, Veronika - Vodičková, Ludmila - Novotný, J. - Hemminki, K. - Vodička, Pavel
MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.
Mutation Research - Genetic Toxicology and Environmental Mutagenesis. Roč. 721, č. 1 (2011), s. 74-80. ISSN 1383-5718. E-ISSN 1879-3592
R&D Projects: GA ČR GP305/09/P194; GA ČR GAP304/10/1286; GA MZd NS10230
Institutional research plan: CEZ:AV0Z50390512
Keywords : Colorectal cancer risk * MTHFR * MTRR
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.035, year: 2011

Polymorphic variants in genes involved in metabolisms of dietary folate may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR and MTRR genes with the risk for colorectal cancer in the Czech Republic. We have concluded that the 677TT genotype and the TA haplotype in the MTHFR gene may also play a role in colorectal cancer risk in the Czech population. No difference in the distribution between cases and controls was observed for the haplotypes based on the four polymorphisms in the MTRR gene.
Permanent Link: http://hdl.handle.net/11104/0202368