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5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes
- 1.0367817 - ÚEM 2012 RIV GB eng J - Journal Article
Pardini, Barbara - Kumar, R. - Naccarati, Alessio - Prasad, R. B. - Försti, A. - Hemminki, K. - Vodička, Pavel - Bermejo, J. L.
5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes.
British Journal of Clinical Pharmacology. Roč. 72, č. 1 (2011), s. 162-163. ISSN 0306-5251. E-ISSN 1365-2125
R&D Projects: GA ČR GAP304/10/1286; GA ČR GP305/09/P194
Institutional research plan: CEZ:AV0Z50390512
Keywords : fluorouracil * DNA-damage * nepolymorphisms
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.958, year: 2011
Treatment with 5-fluorouracil is known to improve survival in various cancers, mainly in colorectal cancer. Crucial metabolite of 5 FU depends on methylene-tetrahydro-folate reductase, MTHFR. We investigated 6 genetic variants in the MTHFR and MTRR genes on the clinical outcome of 273 patients treated by 5FU. One variant in MTHFR gene showed association with progression-free survival in heterozygotes and homozygotes bearers and is connected with statistically significant better survival. None of other investigated variants showed any association with the survival.
Permanent Link: http://hdl.handle.net/11104/0202364
Number of the records: 1