Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

0367814 - ÚEM 2012 RIV US eng J - Journal Article
Winkelmann, J. - Czamara, D. - Schormair, B. - Knauf, F. - Schulte, E. C. - Vodička, Pavel … Total 57 authors
Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1.
PLoS Genetics. Roč. 7, č. 7 (2011), e1002171. ISSN 1553-7390
R&D Projects: GA MZd NR8563
Grant - others:GA MŠk(CZ) MSM0021620849; GA MŠk(CZ) MSM0021620816
Institutional research plan: CEZ:AV0Z50390512
Keywords : TOX3 * transcription * common genetic-variants
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.694, year: 2011

Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age, which severely harms life comfort and working ability. We conducted a genome-wide association study (GWA) for RLS in 922 cases and 1,526 controls (using 301,406 SNPs) followed by a replication of 76 candidate SNPs in 3,935 cases and 5,754 controls, all of European ancestry. We identified several susceptibility loci, two of them novel.
Permanent Link: http://hdl.handle.net/11104/0202361