ANTI-INFLAMMATORY EFFECTS OF CHAMOMILE ESSENTIAL OIL IN MICE

0367752 - ÚŽFG 2012 RIV SK eng J - Journal Article
Fabian, D. - Juhás, Štefan - Bukovska, A. - Bujňáková, D. - Grešáková, L. - Koppel, J.
ANTI-INFLAMMATORY EFFECTS OF CHAMOMILE ESSENTIAL OIL IN MICE.
Slovak Journal of Animal Science. Roč. 44, č. 3 (2011), s. 111-116. ISSN 1335-3683
Institutional research plan: CEZ:AV0Z50450515
Keywords : inflammation * carrageenan paw oedema * TNBS colitis
Subject RIV: EB - Genetics ; Molecular Biology
http://www.cvzv.sk/slju/11_3/Fabian-SJAS-3-2011.pdf

Essential oils are plant secondary metabolites with positive pharmacological properties, e.g. anti-oxidative, antimicrobial or immunomodulative, but they can have toxic and allergic effects as well. The aim of this study was to analyze anti-inflammatory effects of chamomile essential oil dietary administration in carrageenan paw oedema and trinitrobenzene sulfonic acid (TNBS) colitis. Mice received chamomile essential oil in three concentrations (5000, 2500 and 1250 ppm) in the standard rodent diet starting two weeks before induction of carrageenan paw oedema and TNBS colitis. Dietary supplementations with 5000 ppm of chamomile essential oil significantly reduced both the oedema and the weight of mice paws compared with control. The same dose of chamomile essential oil showed protective effect on colonic mucosa and improved macroscopic signs of TNBS-induced colonic inflammation.
Permanent Link: http://hdl.handle.net/11104/0202310