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Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors

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    0367444 - FGÚ 2012 RIV CZ eng J - Journal Article
    Soukup, O. - Krůšek, Jan - Kaniaková, Martina - Kumar, U. K. - Oz, M. - Jun, D. - Fusek, J. - Kuča, K. - Tobin, G.
    Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors.
    Physiological Research. Roč. 60, č. 4 (2011), s. 679-686. ISSN 0862-8408. E-ISSN 1802-9973
    R&D Projects: GA ČR(CZ) GA202/09/0806; GA MŠMT(CZ) LC554
    Grant - others:GA ČR(CZ) GAP303/11/1907
    Institutional research plan: CEZ:AV0Z50110509
    Keywords : organophosphates * patch-clamp * nicotinic receptors * reactivator * isometric muscle contraction * TE671 cells
    Subject RIV: FR - Pharmacology ; Medidal Chemistry
    Impact factor: 1.555, year: 2011

    Antinicotinic properties of oximes reactivators were examined by in-vitro and in-vivo methods. We found that oximes (HI-6, obidoxime, K027 and K203) antagonize the nicotinic receptors of both adult and embryonic form with different potency
    Permanent Link: http://hdl.handle.net/11104/0202135

     
     
Number of the records: 1  

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