Virtual Mutagenesis of the Yeast Cyclins Genetic Network Reveals Complex Dynamics of Transcriptional Control Networks

0367428 - MBÚ 2012 RIV US eng J - Journal Article
Vohradská, E. - Vohradský, Jiří
Virtual Mutagenesis of the Yeast Cyclins Genetic Network Reveals Complex Dynamics of Transcriptional Control Networks.
PLoS ONE. Roč. 6, č. 4 (2011), s. 1-9. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR GA310/07/1009; GA ČR GAP302/11/0229
Institutional research plan: CEZ:AV0Z50200510
Keywords : REGULATORY NETWORKS * SACCHAROMYCES-CEREVISIAE * CELL-CYCLE
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.092, year: 2011

Study of genetic networks has moved from qualitative description of interactions between regulators and regulated genes to the analysis of the interaction dynamics. This paper focuses on the analysis of dynamics of one particular network – the yeast cyclins network. Using a dedicated mathematical model of gene expression and a procedure for computation of the parameters of the model from experimental data, a complete numerical model of the dynamics of the cyclins genetic network was attained. The model allowed for performing virtual experiments on the network and observing their influence on the expression dynamics of the genes downstream in the regulatory cascade. Results show that when the network structure is more complicated, and the regulatory interactions are indirect, results of gene deletion are highly unpredictable
Permanent Link: http://hdl.handle.net/11104/0202124