Number of the records: 1
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat
- 1.0367313 - FGÚ 2012 RIV US eng J - Journal Article
Morrissey, C. - Grieve, I. - Heinig, M. - Atanur, S. - Petretto, E. - Pravenec, Michal - Hubner, N. - Aitman, T. J.
Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.
Physiological Genomics. Roč. 43, č. 21 (2011), s. 1207-1218. ISSN 1094-8341. E-ISSN 1531-2267
R&D Projects: GA ČR(CZ) GA301/08/0166; GA MŠMT(CZ) ME10019
Institutional research plan: CEZ:AV0Z50110509
Keywords : eQTL * spontaneously hypertensive rat * quantitative trait transcript * sequence variation
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.735, year: 2011
The Spontaneously Hypertensive rat (SHR) is a widely used rodent model of hypertension and metabolic syndrome. By integration of genomic sequence, eQTL and QTT datasets we have identified several genes that are strong positional candidates for pathophysiological traits observed in the SHR strain. These findings provide a basis for the functional testing and ultimate elucidation of the molecular basis of these metabolic and cardiovascular phenotypes
Permanent Link: http://hdl.handle.net/11104/0202044
Number of the records: 1