DNA Damage during G2 Phase Does Not Affect Cell Cycle Progression of the Green Alga Scenedesmus quadricauda

0367294 - MBÚ 2012 RIV US eng J - Journal Article
Hlavová, Monika - Čížková, Mária - Vítová, Milada - Bišová, Kateřina - Zachleder, Vilém
DNA Damage during G2 Phase Does Not Affect Cell Cycle Progression of the Green Alga Scenedesmus quadricauda.
PLoS ONE. Roč. 6, č. 5 (2011), s. 1-13. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA AV ČR IAA500200614; GA ČR GA204/09/0111; GA ČR GA525/09/0102
Institutional research plan: CEZ:AV0Z50200510
Keywords : DOUBLE-STRAND BREAKS * P53-DEPENDENT G(1) ARREST * HISTONE H1 KINASE
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.092, year: 2011

DNA damage is a threat to genomic integrity in all living organisms. Plants and green algae are particularly susceptible to DNA damage especially that caused by UV light, due to their light dependency for photosynthesis. For survival of a plant, and other eukaryotic cells, it is essential for an organism to continuously check the integrity of its genetic material and, when damaged, to repair it immediately. Cells therefore utilize a DNA damage response pathway that is responsible for sensing, reacting to and repairing damaged DNA. We have studied the effect of 5-fluorodeoxyuridine, zeocin, caffeine and combinations of these on the cell cycle of the green alga Scenedesmus quadricauda
Permanent Link: http://hdl.handle.net/11104/0202030