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Nanomechanics of magnetically driven cellular endocytosis

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    0367265 - FZÚ 2012 RIV US eng J - Journal Article
    Zablotskyy, Vitaliy A. - Lunov, O. - Dejneka, Alexandr - Jastrabík, Lubomír - Polyakova, T. - Syrovets, T. - Simmet, T.
    Nanomechanics of magnetically driven cellular endocytosis.
    Applied Physics Letters. Roč. 99, č. 18 (2011), 183701/1-183701/3. ISSN 0003-6951. E-ISSN 1077-3118
    R&D Projects: GA AV ČR KAN301370701; GA MŠMT(CZ) 1M06002
    Institutional research plan: CEZ:AV0Z10100522
    Keywords : magnetically controled endocytosis * cell membranes * iron oxide nanoparticles
    Subject RIV: BM - Solid Matter Physics ; Magnetism
    Impact factor: 3.844, year: 2011

    Being essential for many pharmacodynamic and pharmacokinetic processes and playing a crucial role in regulating substrate detachment that enables cellular locomotion, endocytotic mechanisms in many aspects still remain a mystery and therefore can hardly be controlled. Here, we report on experimental and modeling studies of the magnetically assisted endocytosis of functionalized superparamagnetic iron oxide nanoparticles by prostate cancer cells (PC-3) and characterize the time and force scales of the cellular uptake machinery. The results indicate how the cellular uptake rate could be controlled by applied magnetic field, membrane elasticity, and nanoparticle magnetic moment.
    Permanent Link: http://hdl.handle.net/11104/0202008

     
     
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