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Functionalization of osmium arene anticancer complexes with (poly)arginine: Effect on cellular uptake, internalization, and cytotoxicity
- 1.0367048 - BFÚ 2012 RIV US eng J - Journal Article
van Rijt, S.H. - Kostrhunová, Hana - Brabec, Viktor - Sadler, P.J.
Functionalization of osmium arene anticancer complexes with (poly)arginine: Effect on cellular uptake, internalization, and cytotoxicity.
Bioconjugate Chemistry. Roč. 22, č. 2 (2011), s. 218-226. ISSN 1043-1802. E-ISSN 1520-4812
R&D Projects: GA ČR(CZ) GAP301/10/0598
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : osmium * arginine * cellular accumulation
Subject RIV: BO - Biophysics
Impact factor: 4.930, year: 2011
Os complexes conjugated to Arg5 and Arg8 increase Os uptake into A2780 human ovarian cancer cells by 2x and 10x, respectively. A 15-fold increase in binding of Os to DNA was observed for Arg8. The complexes exhibited an ability to precipitate DNA.
Permanent Link: http://hdl.handle.net/11104/0201838
Number of the records: 1