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The diffusion parameters of the extracellular space are altered in focal cortical dysplasias
- 1.0366716 - ÚEM 2012 RIV IE eng J - Journal Article
Vargová, Lýdia - Homola, Aleš - Cicanič, Michal - Kuncová, K. - Kršek, P. - Marusič, P. - Syková, Eva - Zámečník, J.
The diffusion parameters of the extracellular space are altered in focal cortical dysplasias.
Neuroscience Letters. Roč. 499, č. 1 (2011), s. 19-23. ISSN 0304-3940. E-ISSN 1872-7972
Grant - others:GA MZO(CZ) NS9915
Institutional research plan: CEZ:AV0Z50390703
Keywords : epilepsy * focal cortical dysplasia * extracellular diffusion
Subject RIV: FH - Neurology
Impact factor: 2.105, year: 2011
The ECS diffusion parameters were determined using the real-time iontophoretic method in human neocortical tissue samples obtained from surgically treated epileptic patients and correlated with the histologicaly assessed type of cortical dysplasia (FCD type I or II). While the extracellular volume remained unchanged (FCD I) or larger (FCD II) than in normal/control tissue, tortuosity was significantly increased in both types of dysplasia, indicating the presence of additional diffusion barriers and compromised diffusion in dysplastic tissue.
Permanent Link: http://hdl.handle.net/11104/0201605
Number of the records: 1