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Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases
- 1.0366631 - MBÚ 2012 RIV GB eng J - Journal Article
Jančová, P. - Šiller, M. - Anzenbacherová, E. - Křen, Vladimír - Anzenbacher, P. - Šimánek, V.
Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases.
Xenobiotica. Roč. 41, č. 9 (2011), s. 743-751. ISSN 0049-8254. E-ISSN 1366-5928
Institutional research plan: CEZ:AV0Z50200510
Keywords : Silybin * conjugation * metabolism
Subject RIV: CE - Biochemistry
Impact factor: 1.791, year: 2011
The flavonolignan silybin, the main component of silymarin, extract from the seeds of Silybum marianum, is used mostly as a hepatoprotectant. Silybin is almost 1:1 mixture of two diastereomers A and B. The individual UDP-glucuronosyltransferases (UGTs) contributing to the metabolism of silybin diastereomers have not been identified yet. In this study, the contribution of UGTs to silybin metabolism was examined
Permanent Link: http://hdl.handle.net/11104/0201545
Number of the records: 1