Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2

0366527 - BFÚ 2012 RIV US eng J - Journal Article
Pernicová, Zuzana - Slabáková, Eva - Kharaishvili, G. - Bouchal, J. - Král, M. - Kunická, Z. - Machala, M. - Kozubík, Alois - Souček, Karel
Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2.
Neoplasia. Roč. 13, č. 6 (2011), s. 526-536. ISSN 1522-8002
R&D Projects: GA ČR(CZ) GA310/07/0961; GA MZd NS9600; GA MZd NS9956
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : prostate cancer * senescence * Skp2
Subject RIV: BO - Biophysics
Impact factor: 5.946, year: 2011

Here we show that androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces senescence-associated secretory phenotype together with neuroendocrine differentiation in prostate cancer cells. The induction of senescent phenotype was at least in part mediated by down-regulation of Skp2, while neuroendocrine differentiation was under separate control. Induction of senescence may therefore contribute to development of androgen independence in response to androgen deprivation therapy.
Permanent Link: http://hdl.handle.net/11104/0201494