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Computational Modelling of Catalytic Properties and Modified Substrates of Fungal B-N-Acetylhexosaminidases
- 1.0366489 - MBÚ 2012 RIV AE eng J - Journal Article
Kulik, Natallia - Slámová, Kristýna
Computational Modelling of Catalytic Properties and Modified Substrates of Fungal B-N-Acetylhexosaminidases.
Mini - Reviews in Organic Chemistry. Roč. 8, č. 3 (2011), s. 270-280. ISSN 1570-193X. E-ISSN 1875-6298
R&D Projects: GA ČR(CZ) GAP207/11/0629; GA ČR GD305/09/H008; GA MŠMT(CZ) LC06010
Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z60870520
Keywords : beta-N-Acetylhexosaminidase * computer modelling * modified substrate
Subject RIV: CE - Biochemistry
Impact factor: 2.406, year: 2011
Besides their implication in human physiology and disease, b-N-acetylhexosaminidases (EC 3.2.1.52, CAZy GH 20) have recently gained a lot of attention thanks to their great potential in the enzymatic synthesis of carbohydrates and glycomimetics. Extracellular b -N-acetylhexosaminidases from filamentous fungi proved to be a powerful synthetic tool for the preparation of both natural and modified glycosides under mild conditions with good yields. A homology model of b-N-acetylhexosaminidase from the filamentous fungus Aspergillus oryzae has recently been reported, and its quality was corroborated by vibrational spectroscopy and biochemical studies
Permanent Link: http://hdl.handle.net/11104/0201468
Number of the records: 1