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Novel polymeric nanoparticles assembled by metal ion addition
- 1.0366448 - ÚMCH 2012 RIV DE eng J - Journal Article
Škodová, Michaela - Hrubý, Martin - Filippov, Sergey K. - Karlsson, G. - Macková, Hana - Špírková, Milena - Kaňková, Dana - Steinhart, Miloš - Štěpánek, Petr - Ulbrich, Karel
Novel polymeric nanoparticles assembled by metal ion addition.
Macromolecular Chemistry and Physics. Roč. 212, č. 21 (2011), s. 2339-2348. ISSN 1022-1352. E-ISSN 1521-3935
R&D Projects: GA ČR GPP207/10/P054; GA ČR GA202/09/2078; GA MŠMT 1M0505
Institutional research plan: CEZ:AV0Z40500505
Keywords : drug delivery systems * hydroxamic acid * nanoparticles
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 2.361, year: 2011
Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu2+ ions, the self-assembly is slow (within minutes) with low efficiency. With Fe3+ ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity.
Permanent Link: http://hdl.handle.net/11104/0201437
Number of the records: 1