Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

0366420 - FGÚ 2012 RIV GB eng J - Journal Article
Nováková, Marta - Polidarová, Lenka - Sládek, Martin - Sumová, Alena
Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light.
Neuroscience. Roč. 197, - (2011), s. 65-71. ISSN 0306-4522. E-ISSN 1873-7544
R&D Projects: GA ČR(CZ) GA305/09/0321; GA ČR(CZ) GAP303/11/0668; GA MŠMT(CZ) LC554
Grant - others:GA ČR(CZ) GD309/08/H079
Institutional research plan: CEZ:AV0Z50110509
Keywords : circadian system * suprachiasmatic nucleus * restricted feeding * constant light
Subject RIV: FH - Neurology
Impact factor: 3.380, year: 2011

The aim of the study was to elucidate whether feeding regime may affect the molecular mechanisms generating rhythmicity in the suprachiasmatic nucleus (SCN) under conditions in which the rhythmicity is disturbed, as occurs under constant light. Due to exposure to constant light, the rats fed ad libitum became arrhythmic, while those exposed to restricted feeding were active mostly during the time of food availability. Restricted feeding induced significant circadian rhythms in Rev-erbα and Bmal1 gene expression in the SCN. These finding demonstrate that, under specific conditions, when the rhythmicity of the SCN is disturbed and other temporal entraining cues are lacking, the SCN molecular clockwork may likely sense temporal signals from changes in metabolic state delivered by normocaloric food
Permanent Link: http://hdl.handle.net/11104/0201423