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Synthesis and Biological Applications of Glycoconjugates
- 1.0366245 - MBÚ 2012 RIV GB eng M - Monography Chapter
Křen, Vladimír
Glycosidases in Synthesis of Glycomimetics and Unnatural Carbohydrates.
Synthesis and Biological Applications of Glycoconjugates. Velká Británie: Bentham Science Publishers Ltd, 2011 - (Renaudet, O.; Spinelli, N.), s. 226-239. ISBN 978-1-60805-277-6
R&D Projects: GA MŠMT(CZ) LC06010
Institutional research plan: CEZ:AV0Z50200510
Keywords : glycosidase * glycosynthase * thioglycoligase
Subject RIV: CC - Organic Chemistry
In recent years, carbohydrate-processing enzymes have become the enzymes of choice in many applications thanks to their stereoselectivity and efficiency. This chapter presents recent development in glycosidase-catalyzed synthesis of unnatural semisynthetic carbohydrate structures via two complementary approaches: the use of wild-type enzymes with engineered substrates and mutant glycosidases. Genetic engineering has recently produced glucuronyl synthases, an inverting xylosynthase and the first mutant endo-β-N-acetylglucosaminidase
Permanent Link: http://hdl.handle.net/11104/0201299
Number of the records: 1