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Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloir-Glycosyltransferases
- 1.0366242 - MBÚ 2012 RIV DE eng J - Journal Article
Rech, C. - Rosencrantz, R. R. - Křenek, Karel - Pelantová, Helena - Bojarová, Pavla - Roemer, Ch. E. - Hanisch, F.-G. - Křen, Vladimír - Elling, L.
Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloir-Glycosyltransferases.
Advanced Synthesis & Catalysis. Roč. 353, č. 13 (2011), s. 2492-2500. ISSN 1615-4150. E-ISSN 1615-4169
R&D Projects: GA MŠMT OC09045
Institutional research plan: CEZ:AV0Z50200510
Keywords : combinatorial chemistry * biocatalysis * carbohydrates
Subject RIV: CC - Organic Chemistry
Impact factor: 6.048, year: 2011
Poly-N-acetyllactosamine (Poly-LacNAc, [3Galβ1,4GlcNAcβ1]n) glycans play an Essentials role in carbohydrate-protein interactions. The synthesis of poly-LacNAc, both chemical and enzymatic, is typically characterized by high losses of product during sequential synthesis, due to deprotection and/ or purification steps. In this work we present a onepot synthesis of poly-LacNAc oligosaccharides by combining recombinant glycosyltransferases
Permanent Link: http://hdl.handle.net/11104/0201297
Number of the records: 1