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DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: Thermodynamic analysis and chemical probing
- 1.0366089 - BFÚ 2012 RIV DE eng J - Journal Article
Malina, Jaroslav - Farrell, N.P. - Brabec, Viktor
DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: Thermodynamic analysis and chemical probing.
Chemistry-An Asian Journal. Roč. 6, č. 6 (2011), s. 1566-1574. ISSN 1861-4728. E-ISSN 1861-471X
R&D Projects: GA MŠMT(CZ) LC06030; GA MŠMT(CZ) ME10066; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GAP301/10/0598; GA ČR(CZ) GAP205/11/0856
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : calorimetry * DNA damage * interstrand cross-link
Subject RIV: BO - Biophysics
Impact factor: 4.500, year: 2011
The results show that 1,4-interstrand cross-links formed by BBR3464 between two guanine bases in apposite strands exist as two distinct conformers, which are not interconvertible, not only if these cross-links are formed in the 5'-5', but also in the unusual 3'-3' direction.
Permanent Link: http://hdl.handle.net/11104/0201180
Number of the records: 1