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Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface
- 1.0366020 - ÚOCHB 2012 RIV US eng J - Journal Article
Antolíková, Emília - Žáková, Lenka - Turkenburg, J. P. - Watson, C. J. - Hančlová, Ivona - Šanda, Miloslav - Cooper, A. - Kraus, Tomáš - Brzozowski, A. M. - Jiráček, Jiří
Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface.
Journal of Biological Chemistry. Roč. 286, č. 42 (2011), s. 36968-36977. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA MŠMT(CZ) LC06077
Institutional research plan: CEZ:AV0Z40550506
Keywords : insulin * dimer * analog
Subject RIV: CC - Organic Chemistry
Impact factor: 4.773, year: 2011
Using selective N-methylation, we systematically investigated the role of peptide bond amide hydrogens at positions B24, B25 and B26 in insulin for the dimerization ability and for the affinity of the hormone towards insulin receptor.
Permanent Link: http://hdl.handle.net/11104/0201123
Number of the records: 1