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Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand
- 1.0365895 - BFÚ 2012 RIV US eng J - Journal Article
Kisová, Anna - Zerzánková, Lenka - Habtemariam, A. - Sadler, P.J. - Brabec, Viktor - Kašpárková, Jana
Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand.
Molecular Pharmaceutics. Roč. 8, č. 3 (2011), s. 949-957. ISSN 1543-8384. E-ISSN 1543-8392
R&D Projects: GA MŠMT(CZ) LC06030; GA ČR(CZ) GD301/09/H004
Grant - others:GA ČR(CZ) GPP303/11/P047; GA MŠk(CZ) OC09018
Program: GP
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : ruthenium * antitumor * cellular response
Subject RIV: BO - Biophysics
Impact factor: 4.782, year: 2011
The new antitumor monofunctional Ru(II)-arene complex [eta6-arene)Ru(II)(en)Cl]+, where en = [1,2-diaminoethane and the arene is para-terphenyl] inhibits growth of the cancer cells through induction of apoptotic cell death and G0/G1 cell cycle arrest. Further investigations have shown that the ruthenium complex induces apoptosis by regulating the expression of Bc1-2 family proteins.
Permanent Link: http://hdl.handle.net/11104/0006613
Number of the records: 1