Number of the records: 1
Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis
- 1.0365891 - BFÚ 2012 RIV US eng J - Journal Article
Cang, X. - Šponer, Jiří - Cheatham III, T.E.
Insight into G-DNA structural polymorphism and folding from sequence and loop connectivity through free energy analysis.
Journal of the American Chemical Society. Roč. 133, č. 36 (2011), s. 14270-14279. ISSN 0002-7863. E-ISSN 1520-5126
R&D Projects: GA ČR(CZ) GA203/09/1476; GA MŠMT(CZ) LC06030; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GAP208/11/1822
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : molecular dynamics * DNA * quadruplex
Subject RIV: BO - Biophysics
Impact factor: 9.907, year: 2011
The lengths of G-tracts and their connecting loop sequences determine G-quadruplex folding and stability. Here, single-loop G-quadruplexes were investigated using explicit solvent molecular dynamics (MD) simulations to characterize the effect of loop length, loop sequence, and G-tract length on the folding topologies and stability of G-quadruplexes.
Permanent Link: http://hdl.handle.net/11104/0201030
Number of the records: 1