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A single dose of an inhibitor of cyclooxygenase 2, meloxicam, administered shortly after irradiation increases survival of lethally irradiated mice
- 1.0365878 - BFÚ 2012 RIV US eng J - Journal Article
Hofer, Michal - Pospíšil, Milan - Dušek, L. - Hoferová, Zuzana - Weiterová, Lenka
A single dose of an inhibitor of cyclooxygenase 2, meloxicam, administered shortly after irradiation increases survival of lethally irradiated mice.
Radiation Research. Roč. 176, č. 2 (2011), s. 269-272. ISSN 0033-7587. E-ISSN 1938-5404
R&D Projects: GA ČR(CZ) GA305/08/0158
Grant - others:GA ČR(CZ) GAP303/11/0128
Program: GA
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : cyclooxygenase-2 inhibition * lethal irradiation * survival
Subject RIV: BO - Biophysics
Impact factor: 2.684, year: 2011
We have found that meloxicam, a cyclooxygenase-2 inhibitor, administered in a single dose shortly, i.e. 1 hour, after lethal irradiation, increases survival of irradiated mice. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed.
Permanent Link: http://hdl.handle.net/11104/0201020
Number of the records: 1