Intra- and Interindividual Variability in Lymphocyte Chromosomal Aberrations: Implications for Cancer Risk Assessment

0365858 - ÚEM 2012 RIV US eng J - Journal Article
Peters, S. - Portengen, L. - Bonassi, S. - Šrám, Radim - Vermeulen, R.
Intra- and Interindividual Variability in Lymphocyte Chromosomal Aberrations: Implications for Cancer Risk Assessment.
American Journal of Epidemiology. Roč. 174, č. 4 (2011), s. 490-493. ISSN 0002-9262. E-ISSN 1476-6256
Institutional research plan: CEZ:AV0Z50390512
Keywords : chromosomal aberrations frequency * cancer risk assessment
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 5.216, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0365858_01.pdf

Chromosomal aberration (CA) frequency in peripheral lymphocytes of healthy individuals has been found to be predictive of future cancer risk. Intra- and interindividual variability in CA frequency was determined. From a pooled database comprising 11 national cohorts (1965-2002) the authors included 9,433 blood samples from 3,550 subjects with at least one repeated CA measurement. The generalized concordance correlation coeff. of 0.19 was low, indicating high intraindividual variability compared with interindividual variability, resulting in a high likelihood of missclassification. The authors stated that the relation between CA frequency and future cancer risk has probably been underestimated in previous studies.
Permanent Link: http://hdl.handle.net/11104/0201004