Thermal estruction on the nanoscale: Cell membrane hyperthermia with functionalized magnetic nanoparticles

0365855 - FZÚ 2012 RIV US eng C - Conference Paper (international conference)
Lunov, O. - Zablotskyy, Vitaliy A. - Pastor, J. M. - Pérez-Landazábal, J.I. - Gómez-Polo, C. - Syrovets, T. - Simmet, T.
Thermal estruction on the nanoscale: Cell membrane hyperthermia with functionalized magnetic nanoparticles.
8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers. Melville: American institute of physics, 2010 - (Häfeli, U.; Schütt, W.; Zborowski, M.), s. 288-292. AIP Conference Proceedings, 1311. ISBN 978-0-7354-0866-1. ISSN 0094-243X.
[International Conference on the Scientific and Clinical Applications of Magnetic Carriers /8./. Rostock (DE), 25.05.2010-29.05.2010]
Institutional research plan: CEZ:AV0Z10100522
Keywords : magnetic hyperthermia * cell membrane * nanoparticles
Subject RIV: BM - Solid Matter Physics ; Magnetism
http://link.aip.org/link/?APCPCS/1311/288/1

A new mode of hyperthermia, namely hyperthermia with magnetic nanoparticles (MNPs) at the cell membrane, is proposed and analyzed. Clusters of MNPs being positioned on the cell membrane and subjected to an alternative magnetic field are able to significantly elevate the temperature of the cell membrane and to compromise the cellular integrity. A simple model of membrane heating with MNP clusters is proposed. We calculate the spatiotemporal distributions of temperature and demonstrate the applicability of the membrane hyperthermia strategy.
Permanent Link: http://hdl.handle.net/11104/0201001