Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons

0365816 - BFÚ 2012 RIV NL eng J - Journal Article
Andrysík, Zdeněk - Vondráček, Jan - Marvanová, S. - Ciganek, M. - Neča, J. - Pěnčíková, K. - Mahadevan, B. - Topinka, Jan - Baird, W.M. - Kozubík, Alois - Machala, M.
Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 714, 1-2 (2011), s. 53-62. ISSN 0027-5107
R&D Projects: GA ČR(CZ) GA310/07/0961
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : urban air pollution * PAHs * AhR
Subject RIV: BO - Biophysics
Impact factor: 2.850, year: 2011

In the present study we used an organic extract of the urban dust standard reference material, SRM1649a, as a model mixture to study a range of toxic effects related to DNA damage and AhR activation. We found that this extract, as well as its neutral and polar fractions, were potent inducers of a range of AhR-mediated responses. Importantly, these toxic events occurred at doses one order of magnitude lower than induction of DNA damage. Our data suggested that more attention should be paid to the AhR-dependent nongenotoxic events elicited by urban air particulate matter constituents, especially polycyclic aromatic hydrocarbons and their derivatives.
Permanent Link: http://hdl.handle.net/11104/0200970